The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain.

ABSTRACT: Research of the central actions of prolactin is highly focused on females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived signalling in the male mouse brain, employing the immunostaining of phosphorylated signal transducer and activator of transcription 5 (pSTAT5) after exogenous prolactin administration. Next, we explore possible sexually dimorphic differences by comparing pSTAT5 immunoreactivity in prolactin-supplemented males and females. We also assess the role of testosterone in the regulation of central prolactin signalling in males by comparing intact with castrated prolactin-supplemented males. Prolactin-supplemented males displayed a widespread pattern of pSTAT5 immunoreactivit

SUBMITTER: Salais-Lopez H 

PROVIDER: S-EPMC6301622 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature