Statin therapy in the treatment of active cancer: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Preclinical evidence suggests statins may have anti-tumor properties. Large observational studies are also consistent with improved survival and cancer-specific outcomes among cancer patients on statins. We sought to evaluate the randomized controlled trials of statins in addition to usual anti-cancer therapy.

Methods

A systematic search of MEDLINE, Embase, CINAHL, Cochrane Library, Web of Science, Papers First and Clinicaltrials.gov was performed from inception through to July 4, 2017 to identify randomized clinical trials that investigated statin therapy in cancer patients. Our primary outcome was overall survival and our secondary outcome was progression-free survival. We calculated summary hazard ratio's (HR) and 95% confidence intervals (CI) based on random-e

SUBMITTER: Farooqi MAM 

PROVIDER: S-EPMC6301687 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature