Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis.

ABSTRACT: How dietary selection affects genome evolution to define the optimal range of nutrient intake is a poorly understood question with medical relevance. We have addressed this question by analyzing Drosophila simulans and sechellia, recently diverged species with differential diet choice. D. sechellia larvae, specialized to a nutrient scarce diet, did not survive on sugar-rich conditions, while the generalist species D. simulans was sugar tolerant. Sugar tolerance in D. simulans was a tradeoff for performance on low-energy diet and was associated with global reprogramming of metabolic gene expression. Hybridization and phenotype-based introgression revealed the genomic regions of D. simulans that were sufficient for sugar tolerance. These regions incl

SUBMITTER: Melvin RG 

PROVIDER: S-EPMC6301794 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature