Antidiabetic drugs influence molecular mechanisms in prostate cancer.

ABSTRACT:

Background

We investigated the role of diabetes mellitus (DM) and the molecular mechanisms of antidiabetic drugs in prostate cancer (PCa).

Patients and methods

167 patients with both DM and PCa underwent radical prostatectomy (RPE). We divided our patient collective into "metformin" users, "insulin" users, "other antidiabetic drug" users and those with "no antidiabetic drug/diet only" (control group) and analyzed differences in PCa aggressiveness and laboratory parameters among treatment groups. In addition, we generated a tissue-micro-array (TMA) from RPE specimens for the analysis of candidate target pathways of antidiabetic drugs by immunohistochemistry (IHC).

Results

Gleason score of both biopsy and RPE, biopsy undergrading, tumor stage as well as positive resecti

SUBMITTER: Pircher A 

PROVIDER: S-EPMC6301819 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature