Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions.

ABSTRACT: Secretomes from various cell sources exert strong regenerative activities on numerous organs, including the skin. Although secretomes consist of many diverse components, a growing body of evidence suggests that small extracellular vesicles (EVs) account for their regenerative capacity. We previously demonstrated that the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCs) exhibits wound healing capacity. Therefore, we sought to dissect the molecular composition of EVs present in the secretome and compared wound healing-related activities of these EVs to other subfractions of the secretome and the fully supplemented secretome (MNC^aposec). Compared to EVs derived from non-irradiated PBMCs, γ-irradiation significantly increased the size and number and changed the c

SUBMITTER: Wagner T 

PROVIDER: S-EPMC6301954 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature