Agent-Based Modeling Reveals Possible Mechanisms for Observed Aggregation Cell Behaviors.

ABSTRACT: Myxococcus xanthus is a soil bacterium that serves as a model system for biological self-organization. Cells form distinct, dynamic patterns depending on environmental conditions. An agent-based model was used to understand how M. xanthus cells aggregate into multicellular mounds in response to starvation. In this model, each cell is modeled as an agent represented by a point particle and characterized by its position and moving direction. At low agent density, the model recapitulates the dynamic patterns observed by experiments and a previous biophysical model. To study aggregation at high cell density, we extended the model based on the recent experimental observation that cells exhibit biased movement toward aggregates. We tested two possible mechanisms for this biased movement and demo

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6301987 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature