Thermodynamic Modeling of the Statistics of Cell Spreading on Ligand-Coated Elastic Substrates.

ABSTRACT: Biological spread cells exist in a perpetually fluctuating state and therefore cannot be described in terms of a unique deterministic system. For modeling approaches to provide novel insight and uncover new mechanisms that drive cell behavior, a framework is required that progresses from traditional deterministic methods (whereby simulation of an experiment predicts a single outcome). In this study, we implement a new, to our knowledge, modeling approach for the analysis of cell spreading on ligand-coated substrates, extending the framework for nonequilibrium thermodynamics of cells developed by Shishvan et al. to include active focal adhesion assembly. We demonstrate that the model correctly predicts the coupled influence of surface collagen density and substrate stiffness on cell spreadi

SUBMITTER: McEvoy E 

PROVIDER: S-EPMC6301989 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature