MPGES-1-Mediated Production of PGE₂ and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.

ABSTRACT: PGE₂ is a lipid mediator of the initiation and resolution phases of inflammation, as well as a regulator of immune system responses to inflammatory events. PGE₂ is produced and sensed by T cells, and autocrine or paracrine PGE₂ can affect T cell phenotype and function. In this study, we use a T cell-dependent model of colitis to evaluate the role of PGE₂ on pathological outcome and T-cell phenotypes. CD4⁺ T effector cells either deficient in mPGES-1 or the PGE₂ receptor EP4 are less colitogenic. Absence of T cell autocrine mPGES1-dependent PGE₂ reduces colitogenicity in association with an increase in CD4⁺RORγt⁺ cells in the lamina propria. In contrast, recipient mice deficient in mPGES-1 exh

SUBMITTER: Maseda D 

PROVIDER: S-EPMC6302013 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature