Predicting Collective Migration of Cell Populations Defined by Varying Repolarization Dynamics.

ABSTRACT: Collective migration of heterogeneous cell populations is an essential aspect of fundamental biological processes, including morphogenesis, wound healing, and tumor invasion. Through experiments and modeling, it has been shown that cells attain front-rear polarity, generate forces, and form adhesions to migrate. However, it remains unclear how the ability of individual cells in a population to dynamically repolarize themselves into new directions could regulate the collective response. We present a vertex-based model in which each deformable cell randomly chooses a new polarization direction after every defined time interval, elongates, proportionally generates forces, and causes collective migration. Our simulations predict that cell types that repolarize at longer time intervals attain m

SUBMITTER: Mathur J 

PROVIDER: S-EPMC6302036 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature