Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.

ABSTRACT:

Background

In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component.

Methods

For this purpose, we performed a cross-disease meta-analysis of Immunochip data from 37,159 patients diagnosed with a seropositive autoimmune disease (11,489 celiac disease (CeD), 15,523 rheumatoid arthritis (RA), 3477 systemic sclerosis (SSc), and 6670 type 1 diabetes (T1D)) and 22,308 healthy controls of European origin using the R package ASSET.

Results

We identified 38 risk variants shared by at least two of the conditions analyzed, five of which represent new pleiotropic lo

SUBMITTER: Marquez A 

PROVIDER: S-EPMC6302306 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature