Metabolomics of mammalian brain reveals regional differences.

ABSTRACT:

Background

The mammalian brain is organized into regions with specific biological functions and properties. These regions have distinct transcriptomes, but little is known whether they may also differ in their metabolome. The metabolome, a collection of small molecules or metabolites, is at the intersection of the genetic background of a given cell or tissue and the environmental influences that affect it. Thus, the metabolome directly reflects information about the physiologic state of a biological system under a particular condition. The objective of this study was to investigate whether various brain regions have diverse metabolome profiles, similarly to their genetic diversity. The answer to this question would suggest that not only the genome but also the metabolome may contri

SUBMITTER: Choi WT 

PROVIDER: S-EPMC6302375 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature