Genetics of rotator cuff tears: no association of col5a1 gene in a case-control study.

ABSTRACT: BACKGROUND:The incidence of RC tears increases with aging, affecting approximately 30 to 50% of individuals older than 50 years, and more than 50% of individuals older than 80 years. Intrinsic factors (age or gender), extrinsic factors (sports activity or occupation), and biological factors were identified in the onset and progression of RC tears. The attention in the study of aetiology of RC tendinopathy has shifted to the identification of gene variants. Genes encoding for proteins regulating the concentration of pyrophosphate in the extracellular matrix and genes encoding for fibroblastic growth factors, defensin beta 1 and estrogen-related receptor-beta were analyzed. However, only in one study the role of variants of collagen type V alpha 1 (col5a1) gene in RC tears was assessed. The

SUBMITTER: Longo UG 

PROVIDER: S-EPMC6302427 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature