Gut colonization by a novel Clostridium species is associated with the onset of epizootic rabbit enteropathy.

ABSTRACT: Epizootic rabbit enteropathy (ERE) represents one of the most devastating diseases affecting rabbit farms. Previous studies showing transmissibility of disease symptoms through oral inoculation of intestinal contents from sick animals suggested a bacterial infectious origin for ERE. However, no etiological agent has been identified yet. On the other hand, ERE is associated with major changes in intestinal microbial communities, pinpointing dysbiosis as an alternative cause for the disease. To better understand the role of intestinal bacteria in ERE development, we have performed a prospective longitudinal study in which intestinal samples collected from the same animals before, during and after disease onset were analyzed using high-throughput sequencing. Changes in hundreds of bacterial g

SUBMITTER: Djukovic A 

PROVIDER: S-EPMC6302431 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature