A novel deletion in KRT75L4 mediates the frizzle trait in a Chinese indigenous chicken.

ABSTRACT:

Background

Highly diversified in morphology and structure, feathers have evolved into various forms. Frizzle feathers, which result from a developmental defect of the feather, are observed in several domestic chicken breeds. The frizzle phenotype is consistent with incomplete dominance of a major gene, but the molecular mechanisms that underlie this phenotype remain obscure. Kirin, a Chinese indigenous chicken breed that originated in the Guangdong province, is famous for its frizzle feathers. The KRT75 gene is considered as the dominant gene responsible for the frizzle trait in several chicken breeds, but this is not the case in the Kirin breed. Thus, the objective of our study was to investigate the genomic region and mutation responsible for this phenotype in this particular bre

SUBMITTER: Dong J 

PROVIDER: S-EPMC6302451 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature