Integrating proteomic and phosphoproteomic data for pathway analysis in breast cancer.

ABSTRACT:

Background

As protein is the basic unit of cell function and biological pathway, shotgun proteomics, the large-scale analysis of proteins, is contributing greatly to our understanding of disease mechanisms. Proteomics study could detect the changes of both protein expression and modification. With the releases of large-scale cancer proteome studies, how to integrate acquired proteomic and phosphoproteomic data in more comprehensive pathway analysis becomes implemented, but remains challenging. Integrative pathway analysis at proteome level provides a systematic insight into the signaling network adaptations in the development of cancer.

Results

Here we integrated proteomic and phosphoproteomic data to perform pathway prioritization in breast cancer. We manually collected and

SUBMITTER: Ren J 

PROVIDER: S-EPMC6302460 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature