Multiple transcription factors contribute to inter-chromosomal interaction in yeast.

ABSTRACT:

Background

Chromatin interactions medicated by genomic elements located throughout the genome play important roles in gene regulation and can be identified with the technologies such as high-throughput chromosome conformation capture (Hi-C), followed by next-generation sequencing. These techniques were wildly used to reveal the relative spatial disposition of chromatins in human, mouse and yeast. Unlike metazoan where CTCF plays major roles in mediating chromatin interactions, in yeast, the transcription factors (TFs) involved in this biological process are poorly known.

Results

Here, we presented two computational approaches to estimate the TFs enriched in the chromatin physical inter-chromosomal interactions in yeast. Through the Chi-square method, we found TFs whose bindi

SUBMITTER: Dai Y 

PROVIDER: S-EPMC6302461 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature