Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort.

ABSTRACT:

Background

Subjective cognitive decline (SCD) consists of self-perceived decline in cognition over time. The occurrence of specific additional features in SCD (so-called SCDplus) confers a higher risk of future cognitive decline. However, it is not known whether SCDplus patients have a distinct cognitive and neuroimaging profile. Therefore, we aimed to study the associations between SCDplus features and cognitive and neuroimaging profiles in a population-based cohort.

Methods

A total of 2670 individuals from the ALFA cohort underwent clinical, cognitive, and MRI (n = 532) explorations. Subjects were classified as self-reporting cognitive decline (SCD) or not self-reporting cognitive decline (non-SCD). Within the SCD group, participants were also classified according to the n

SUBMITTER: Sanchez-Benavides G 

PROVIDER: S-EPMC6302483 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature