The adipose tissue stromal vascular fraction secretome enhances the proliferation but inhibits the differentiation of myoblasts.

ABSTRACT:

Background

Adipose tissue is an excellent source for isolation of stem cells for treating various clinical conditions including injuries to the neuromuscular system. Many previous studies have focused on differentiating these adipose stem cells (ASCs) towards a Schwann cell-like phenotype (dASCs), which can enhance axon regeneration and reduce muscle atrophy. However, the stromal vascular fraction (SVF), from which the ASCs are derived, also exerts broad regenerative potential and might provide a faster route to clinical translation of the cell therapies for treatment of neuromuscular disorders.

Methods

The aim of this study was to establish the effects of SVF cells on the proliferation and differentiation of myoblasts using indirect co-culture experiments. A Growth Factor P

SUBMITTER: El-Habta R 

PROVIDER: S-EPMC6302486 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature