Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation.

ABSTRACT:

Background

Spinal reactive astrocytes and microglia are known to participate to the initiation and maintenance of neuropathic pain. However, whether reactive astrocytes and microglia in thalamic nuclei that process sensory-discriminative aspects of pain play a role in pain behavior remains poorly investigated. Therefore, the present study evaluated whether the presence of reactive glia (hypertrophy, increased number and upregulation of glial markers) in the ventral posterolateral thalamic nucleus (VPL) correlates with pain symptoms, 14 and 28 days after unilateral L5/L6 spinal nerve ligation (SNL) in rats.

Methods

Mechanical allodynia and hyperalgesia (von Frey filament stimulation) as well as ambulatory pain (dynamic weight bearing apparatus) were assessed. Levels of nine g

SUBMITTER: Blaszczyk L 

PROVIDER: S-EPMC6302506 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature