Elevated CD3^low double negative T lymphocyte is associated with pneumonia and its severity in pediatric patients.

ABSTRACT:

Background

Previous studies have shown that the adaptive immunity function of T cells in disease states correlates with CD3 surface expression closely. During routine assessment of TBNK subsets in peripheral blood of pediatric patients by flow cytometry, we noticed that variable expression levels of CD3 on CD3⁺CD4^-CD8^- double-negative T (DNT) lymphocytes in different patients. The objective of this study was to assess the relationship of CD3 expression levels on DNT cells with disease severity.

Methods

In this prospective study, we investigated the frequencies of circulating CD4^-CD8^- DNT cell subsets with CD3^low or CD3^high phenotype by flow cytometry in 76 pediatric patients with pneumonia, 55 patie

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6302782 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature