Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study.

ABSTRACT:

Background

Previous studies have shown a link between increased dietary intake of arachidonic acid (ARA) and colorectal neoplasms. It has been shown that erythrocyte phospholipid membrane concentrations of ARA are strongly determined by genetic variation. Fatty acid desaturase (FADS) controls the rate limiting step in ARA production, and FADS variant rs174537 has been shown to be responsible for up to 18.6% of the variation seen. To determine if a causal association exists between erythrocyte membrane ARA concentrations and colorectal adenomas, we conducted a Mendelian randomization (MR) analysis using rs174537 as an instrumental variable (IV). MR analysis was chosen because it is less susceptible to bias and confounding.

Patients and methods

A case-control study was perform

SUBMITTER: Isom CA 

PROVIDER: S-EPMC6302799 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature