Low periostin expression predicts poor survival in intestinal type gastric cancer patients.

ABSTRACT:

Background and aim

Periostin is a protein from the Fascilin family. It is commonly present in normal tissues and is responsible for cell adhesion. Evidence has emerged showing that changes in periostin expression play an important role in tumor initiation, development, and progression. This study aims to investigate the effect of periostin in gastric cancer (GC) patients who underwent gastrectomy. Seven hundred and forty-seven GC patients who underwent gastrectomy between December 2006 and July 2011 were included in this study.

Methods

Seven hundred and forty-seven cancer tissues and 70 paired adjacent normal tissues were collected. Periostin expression was evaluated by immunohistochemistry. The Gene Expression Omnibus database was used to study the association between the m

SUBMITTER: Zhang T 

PROVIDER: S-EPMC6302807 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature