Follow-up infarct volume as a mediator of endovascular treatment effect on functional outcome in ischaemic stroke.

ABSTRACT:

Objective

The putative mechanism for the favourable effect of endovascular treatment (EVT) on functional outcome after acute ischaemic stroke is preventing follow-up infarct volume (FIV) progression. We aimed to assess to what extent difference in FIV explains the effect of EVT on functional outcome in a randomised trial of EVT versus no EVT (MR CLEAN).

Methods

FIV was assessed on non-contrast CT scan 5-7 days after stroke. Functional outcome was the score on the modified Rankin Scale at 3 months. We tested the causal pathway from intervention, via FIV to functional outcome with a mediation model, using linear and ordinal regression, adjusted for relevant baseline covariates, including stroke severity. Explained effect was assessed by taking the ratio of the log odds ratios

SUBMITTER: Compagne KCJ 

PROVIDER: S-EPMC6302877 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature