Transcriptional trajectories of human kidney injury progression.

ABSTRACT:

Background

The molecular understanding of the progression from acute to chronic organ injury is limited. Ischemia/reperfusion injury (IRI) triggered during kidney transplantation can contribute to progressive allograft dysfunction.

Methods

Protocol biopsies (n = 163) were obtained from 42 kidney allografts at 4 time points after transplantation. RNA sequencing-mediated (RNA-seq-mediated) transcriptional profiling and machine learning computational approaches were employed to analyze the molecular responses to IRI and to identify shared and divergent transcriptional trajectories associated with distinct clinical outcomes. The data were compared with the response to IRI in a mouse model of the acute to chronic kidney injury transition.

Results

In the first hours after r

SUBMITTER: Cippa PE 

PROVIDER: S-EPMC6302941 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature