Ontology highlight
ABSTRACT:
SUBMITTER: Zhong F
PROVIDER: S-EPMC6302948 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zhong Fang F Chen Zhaohong Z Zhang Liwen L Xie Yifan Y Nair Viji V Ju Wenjun W Kretzler Matthias M Nelson Robert G RG Li Zhengzhe Z Chen Hongyu H Wang Yongjun Y Zhang Aihua A Lee Kyung K Liu Zhihong Z He John Cijiang JC
JCI insight 20181115 22
Our previous work demonstrated a protective role of protein S in early diabetic kidney disease (DKD). Protein S exerts antiinflammatory and antiapoptotic effects through the activation of TYRO3, AXL, and MER (TAM) receptors. Among the 3 TAM receptors, we showed that the biological effects of protein S were mediated largely by TYRO3 in diabetic kidneys. Our data now show that TYRO3 mRNA expression is highly enriched in human glomeruli and that TYRO3 protein is expressed in podocytes. Interestingl ...[more]