Age at menarche and childhood body mass index as predictors of cardio-metabolic risk in young adulthood: A prospective cohort study.

ABSTRACT:

Objective

This study aimed to examine the association between age at menarche and a range of cardiovascular disease (CVD) risk factors at 17 and 20 years of age, and whether this was influenced by childhood body mass index (BMI).

Methods

Of the 1413 girls born in the Western Australian Pregnancy Cohort (Raine) Study, 846 had age at menarche recorded. Subsequently 557 underwent metabolic assessment at 17 years and 541 at 20 years. Associations between age at menarche and cardiovascular risk factors, and being in a high-risk metabolic cluster at 17 and 20 years, or having the metabolic syndrome at 20 years, were investigated by linear mixed effects and logistic regressions, respectively.

Results

Each year later of onset of menarche was associated with a 0.75 kg/m2 reduc

SUBMITTER: Le-Ha C 

PROVIDER: S-EPMC6303033 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature