Brain transcriptome changes in the aging Drosophila melanogaster accompany olfactory memory performance deficits.

ABSTRACT: Cognitive decline is a common occurrence of the natural aging process in animals and studying age-related changes in gene expression in the brain might shed light on disrupted molecular pathways that play a role in this decline. The fruit fly is a useful neurobiological model for studying aging due to its short generational time and relatively small brain size. We investigated age-dependent changes in the Drosophila melanogaster whole-brain transcriptome by comparing 5-, 20-, 30- and 40-day-old flies of both sexes. We used RNA-Sequencing of dissected brain samples followed by differential expression, temporal clustering, co-expression network and gene ontology enrichment analyses. We found an overall decline in expression of genes from the mitochondrial oxidative phosphorylation pathway th

SUBMITTER: Pacifico R 

PROVIDER: S-EPMC6303037 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature