Ontology highlight
ABSTRACT:
SUBMITTER: Pettinati I
PROVIDER: S-EPMC6303110 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
eLife 20181203
Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole endonuclease responsible for 3' end processing of both mRNA classes. We report cellular, genetic, biochemical, substrate selectivity, and crystallographic studies providing evidence ...[more]