Chemotaxis Model for Breast Cancer Cells Based on Signal/Noise Ratio.

ABSTRACT: Chemotaxis, a biased migration of cells under a chemical gradient, plays a significant role in diverse biological phenomena including cancer metastasis. Stromal cells release signaling proteins to induce chemotaxis, which leads to organ-specific metastasis. Epidermal growth factor (EGF) is an example of the chemical attractants, and its gradient stimulates metastasis of breast cancer cells. Hence, the interactions between EGF and breast cancer cells have long been a subject of interest for oncologists and clinicians. However, most current approaches do not systematically separate the effects of gradient and absolute concentration of EGF on chemotaxis of breast cancer cells. In this work, we develop a theoretical model based on signal/noise ratio to represent stochastic properties and repor

SUBMITTER: Lim S 

PROVIDER: S-EPMC6303234 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature