Prickle1 regulates differentiation of frontal bone osteoblasts.

ABSTRACT: Enlarged fontanelles and smaller frontal bones result in a mechanically compromised skull. Both phenotypes could develop from defective migration and differentiation of osteoblasts in the skull bone primordia. The Wnt/Planar cell polarity (Wnt/PCP) signaling pathway regulates cell migration and movement in other tissues and led us to test the role of Prickle1, a core component of the Wnt/PCP pathway, in the skull. For these studies, we used the missense allele of Prickle1 named Prickle1^Beetlejuice (Prickle1^Bj). The Prickle1^Bj/Bj mutants are microcephalic and develop enlarged fontanelles between insufficient frontal bones, while the parietal bones are normal. Prickle1^Bj/Bj mutants have several other craniofacial defects including a midline cleft l

SUBMITTER: Wan Y 

PROVIDER: S-EPMC6303328 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature