Impaired immune surveillance accelerates accumulation of senescent cells and aging.

ABSTRACT: Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. However, senescent cells accumulate in tissues in advanced age, where they might promote tissue degeneration and malignant transformation. The extent of immune-system involvement in regulating age-related accumulation of senescent cells, and its consequences, are unknown. Here we show that Prf1^-/- mice with impaired cell cytotoxicity exhibit both higher senescent-cell tissue burden and chronic inflammation. They suffer from multiple age-related disorders and lower survival. Strikingly, pharmacological elimination of senescent-cells by ABT-737 partially alleviates accelerated aging phenotype in these mice. In LMNA^+/G609G progeroid mi

SUBMITTER: Ovadya Y 

PROVIDER: S-EPMC6303397 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature