Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles.

ABSTRACT: Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward, their ultrastructural composition and microenvironment at the nanoscale have remained unclear so far, as has their relevance to aging and certain disease states that involve the sequestration of toxic cellular metabolites. Here, we apply correlative serial block-face scanning electron microscopy and transmission electron tomography to gain three-dimensional insight into the ultrastructure and surrounding microenvironment of cerebral Corpora amylacea in the human brainstem and hippocampal region. We find that cerebral Corpora amylacea are composed of dense labyrinth-like sheets of lipid membranes, contain vesicles as well as morphologi

SUBMITTER: Navarro PP 

PROVIDER: S-EPMC6303404 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature