Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models.

ABSTRACT:

Background

Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis.

Objective

The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models.

Methods

In formaldehyde model, sub-plantar administration of 0.1 ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3 mg/kg, p.o.) and three groups, treated with 50, 100 and 200 mg/kg CCHE (p.o.). Joint diameter was measured, and ankle joints were collected for MDA and GSH measurements. In complete Freund's adjuvant (CFA)-induced arthritis m

SUBMITTER: Sharma H 

PROVIDER: S-EPMC6303416 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature