Role of the Interaction Motif in Maintaining the Open Gate of an Open Sodium Channel.

ABSTRACT: Voltage-gated sodium channels undergo transitions between open, closed, and inactivated states, enabling regulation of the translocation of sodium ions across membranes. A recently published crystal structure of the full-length prokaryotic NavMs crystal structure in the activated open conformation has revealed the presence of a novel motif consisting of an extensive network of salt bridges involving residues in the voltage sensor, S4-S5 linker, pore, and C-terminal domains. This motif has been proposed to be responsible for maintaining an open conformation that enables ion translocation through the channel. In this study, we have used long-time molecular dynamics calculations without artificial restraints to demonstrate that the interaction network of full-length NavMs indeed prevents a ra

SUBMITTER: Ke S 

PROVIDER: S-EPMC6303419 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature