Distinct genomic profile and specific targeted drug responses in adult cerebellar glioblastoma.

ABSTRACT:

Background

Despite extensive efforts on the genomic characterization of gliomas, very few studies have reported the genetic alterations of cerebellar glioblastoma (C-GBM), a rare and lethal disease. Here, we provide a systematic study of C-GBM to better understand its specific genomic features.

Methods

We collected a cohort of C-GBM patients and compared patient demographics and tumor pathologies with supratentorial glioblastoma (S-GBM). To uncover the molecular characteristics, we performed DNA and mRNA sequencing and DNA methylation arrays on 19, 6, and 4 C-GBM cases, respectively. Moreover, chemical drug screening was conducted to identify potential therapeutic options for C-GBMs.

Results

Despite differing anatomical origins of C-GBM and S-GBM, neither histological

SUBMITTER: Cho HJ 

PROVIDER: S-EPMC6303467 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature