Broad CD8⁺ T cell cross-recognition of distinct influenza A strains in humans.

ABSTRACT: Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of the virus due to minimal antibody-mediated immunity. In that case, established CD8⁺ T-cells can reduce disease severity. However, as mutations occur sporadically within immunogenic IAV-derived T-cell peptides, understanding of T-cell receptor (TCRαβ) cross-reactivity towards IAV variants is needed for a vaccine design. Here, we investigate TCRαβ cross-strain recognition across IAV variants within two immunodominant human IAV-specific CD8⁺ T-cell epitopes, HLA-B*37:01-restricted NP_338-346 (B37-NP₃₃₈) and HLA-A*01:01-restricted NP_44-52 (A1-NP₄₄). We find high abundance of cross-reactive TCRαβ clonotypes recognizing distinct IAV v

SUBMITTER: Grant EJ 

PROVIDER: S-EPMC6303473 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature