Bioinformatic identification of key genes and pathways that may be involved in the pathogenesis of HBV-associated acute liver failure.

ABSTRACT: In order to explore the molecular mechanisms behind the pathogenesis of acute liver failure (ALF) associated with hepatitis B virus (HBV) infection, the present study aimed to identify potential key genes and pathways involved using samples from patients with HBV-associated ALF. The GSE38941 array dataset was downloaded from the Gene Expression Omnibus database, and differentially expressed genes (DEGs) between 10 liver samples from 10 healthy donors and 17 liver specimens from 4 patients with HBV-associated ALF were analyzed using the Linear Models for Microarray Data package. Gene Ontology and KEGG pathway enrichment analyses of the DEGs were performed, followed by functional annotation of the genes and construction of a protein-protein interaction (PPI) network. Subnetwork modules were

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6303483 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature