Regulatory principles governing the maternal-to-zygotic transition: insights from Drosophila melanogaster.

ABSTRACT: The onset of metazoan development requires that two terminally differentiated germ cells, a sperm and an oocyte, become reprogrammed to the totipotent embryo, which can subsequently give rise to all the cell types of the adult organism. In nearly all animals, maternal gene products regulate the initial events of embryogenesis while the zygotic genome remains transcriptionally silent. Developmental control is then passed from mother to zygote through a process known as the maternal-to-zygotic transition (MZT). The MZT comprises an intimately connected set of molecular events that mediate degradation of maternally deposited mRNAs and transcriptional activation of the zygotic genome. This essential developmental transition is conserved among metazoans but is perhaps best understood in the fru

SUBMITTER: Hamm DC 

PROVIDER: S-EPMC6303782 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature