The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease.

ABSTRACT:

Background

Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer's disease (AD), such as metabolic, cardiovascular, and cerebrovascular disease.

Methods

In this study, we tested whether TMAO is linked to AD by examining TMAO levels in cerebrospinal fluid (CSF) collected from a large sample (n = 410) of individuals with Alzheimer's clinical syndrome (n = 40), individuals with mild cognitive impairment (MCI) (n = 35), and cognitively-unimpaired individuals (n = 335). Linear regression analyses were used to determine differences in CSF TMAO between groups (controlling for age, sex, and APOE ε4 genotype), as well as to determine re

SUBMITTER: Vogt NM 

PROVIDER: S-EPMC6303862 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature