Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells.

ABSTRACT:

Background

Pancreatic cancer (PC) is a highly aggressive disease, and the lethality of this disease stems from early metastatic dissemination where surgical removal cannot provide a cure. Improvement of the therapeutic outcome and overall survival of PC patients requires to understand the fundamental processes that lead to metastasis such as the gain of cellular migration ability. One such family of proteins, which are essential players of cellular migration, is Semaphorin. Previously, we have identified one of the Semaphorin family member, Semaphorin-5A (SEMA5A) to be involved in organ-specific homing during PC metastasis. We have also demonstrated that SEMA5A has a constitutive expression in PC cell lines derived from metastatic sites in comparison with low endogenous expression

SUBMITTER: Saxena S 

PROVIDER: S-EPMC6303891 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature