Osthole inhibits triple negative breast cancer cells by suppressing STAT3.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is an aggressive subgroup of human breast cancer. Patients with TNBC have poor clinical outcome as they are non-responsive to current targeted therapies. There is an urgent need to identify new therapeutic targets and develop more effective treatment options for TNBC patients. Osthole, a natural product from C. monnieri, has been shown to inhibit certain cancer cells. However, the mechanisms of action as well as its effect on TNBC cells are not currently known.

Methods

We investigated the effect of osthole in cultured TNBC cells as well as in a xenograft model of TNBC growth. We also used a high-throughput proteomics platform to identify the direct binding protein of osthole.

Results

We found that osthole inhibited the g

SUBMITTER: Dai X 

PROVIDER: S-EPMC6303899 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature