Capturing context-specific regulation in molecular interaction networks.

ABSTRACT:

Background

Molecular profiles change in response to perturbations. These changes are coordinated into functional modules via regulatory interactions. The genes and their products within a functional module are expected to be differentially expressed in a manner coherent with their regulatory network. This perspective presents a promising approach to increase precision in detecting differential signals as well as for describing differential regulatory signals within the framework of a priori knowledge about the underlying network, and so from a mechanistic point of view.

Results

We present Coherent Network Expression (CoNE), an effective procedure for identifying differentially activated functional modules in molecular interaction networks. Differential gene expression is cho

SUBMITTER: Rush STA 

PROVIDER: S-EPMC6303932 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature