Bridging trees for posterior inference on ancestral recombination graphs.

ABSTRACT: We present a new Markov chain Monte Carlo algorithm, implemented in the software Arbores, for inferring the history of a sample of DNA sequences. Our principal innovation is a bridging procedure, previously applied only for simple stochastic processes, in which the local computations within a bridge can proceed independently of the rest of the DNA sequence, facilitating large-scale parallelization.

SUBMITTER: Heine K 

PROVIDER: S-EPMC6304023 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature