Insulin signalling's role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus.

ABSTRACT: Organisms cope with nutritional variation via developmental plasticity, adjusting trait size to nutrient availability for some traits while enabling others to develop in a nutritionally robust manner. Yet, the developmental mechanisms that regulate organ-specific growth across nutritional gradients remain poorly understood. We assessed the functions of members of the insulin/insulin-like signalling pathway (IIS) in the regulation of nutrition sensitivity and robustness in males of the horn-polyphenic beetle Onthophagus taurus, as well as potential regulatory interactions between IIS and two other growth-regulating pathways: Doublesex and Hedgehog signalling. Using RNA interference (RNAi), we experimentally knocked down both insulin receptors ( InR1 and InR2) and Foxo, a growth inhibitor. W

SUBMITTER: Casasa S 

PROVIDER: S-EPMC6304051 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature