Long noncoding RNA SNHG15 serves as an oncogene and predicts poor prognosis in epithelial ovarian cancer.

ABSTRACT:

Objective

This study aims to investigate the functional role of long noncoding RNA SNHG15 in epithelial ovarian cancer (EOC).

Materials and methods

The expression of SNHG15 was measured in EOC cells and tissues using qRT-PCR. The correlation of SNHG15 expression and the clinicopathological characters was statistically analyzed. The prognosis of patients with different clinical features in the high/low SNHG15 expression groups were calculated. Moreover, univariate and multivariate Cox regression analyses were performed to identify the risk factors for poor overall survival (OS) and progression-free survival (PFS). The effect of SNHG15 on the migration and invasion was evaluated using Transwell and Matrigel, respectively. The proliferation ability of EOC cells was tested using

SUBMITTER: Qu C 

PROVIDER: S-EPMC6304080 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature