Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma.

ABSTRACT: Background: Potential prognostic biomarker candidates for hepatocellular carcinoma (HCC) are abundant, but their generalizability is unexplored. We cross-validated markers of overall survival (OS) and vascular invasion in independent datasets. Methods: The literature search yielded 318 genes related to survival and 52 related to vascular invasion. Validation was performed in three datasets (RNA-seq, n = 371; Affymetrix arrays, n = 91; Illumina gene chips, n = 135) by uni- and multivariate Cox regression and Mann-Whitney U-test, separately for Asian and Caucasian patients. Results: One hundred and eighty biomarkers remained significant in Asian and 128 in Caucasian subjects at p < 0.05. After multiple testing correction BIRC5 (<

SUBMITTER: Menyhart O 

PROVIDER: S-EPMC6304123 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature