Diagnosis and treatment of lipodystrophy: a step-by-step approach.

ABSTRACT:

Aim

Lipodystrophy syndromes are rare heterogeneous disorders characterized by deficiency of adipose tissue, usually a decrease in leptin levels and, frequently, severe metabolic abnormalities including diabetes mellitus and dyslipidemia.

Purpose

To describe the clinical presentation of known types of lipodystrophy, and suggest specific steps to recognize, diagnose and treat lipodystrophy in the clinical setting.

Methods

Based on literature and in our own experience, we propose a stepwise approach for diagnosis of the different subtypes of rare lipodystrophy syndromes, describing its more frequent co-morbidities and establishing the therapeutical approach.

Results

Lipodystrophy is classified as genetic or acquired and by the distribution of fat loss, which can b

SUBMITTER: Araujo-Vilar D 

PROVIDER: S-EPMC6304182 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature