Targeting CDC7 improves sensitivity to chemotherapy of esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

The cell division cycle 7 (CDC7) is a serine/threonine kinase that is essential for DNA replication in human cells which has been identified to play a critical role in multiple cancer types. However, the expression and clinical significance of CDC7 in ESCC has never been reported.

Patients and methods

CDC7 expression was detected in 30 ESCC and matched adjacent normal tissues, and a series of loss-of-function and gain-of-function assays were performed to evaluate the effects of CDC7 on the proliferation, migration and invasion, and chemoresistance of ESCC cells.

Results

The results showed that CDC7 was highly expressed in ESCC tissues compared with matched adjacent normal tissues. Functional studies demonstrated that knockdown of CDC7 inhibited proliferation b

SUBMITTER: Cao JX 

PROVIDER: S-EPMC6304257 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature