Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016.

ABSTRACT:

Background

Six amino acid positions (145, 155, 156, 158, 159, and 189, referred to as the antigenic motif; H3 numbering) in the globular head region of hemagglutinin (HA1 domain) play an important role in defining the antigenic phenotype of swine Clade IV (C-IV) H3N2 IAV, containing an H3 from a late 1990s human-to-swine introduction. We hypothesized that antigenicity of a swine C-IV H3 virus could be inferred based upon the antigenic motif if it matched a previously characterized antigen with the same motif. An increasing number of C-IV H3 genes encoding antigenic motifs that had not been previously characterized were observed in the U.S. pig population between 2012 and 2016.

Objectives

A broad panel of contemporary H3 viruses with uncharacterized antigenic motifs was selec

SUBMITTER: Bolton MJ 

PROVIDER: S-EPMC6304321 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature