GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders.

ABSTRACT: Complex aging-triggered disorders are multifactorial programs that comprise a myriad of alterations in interconnected protein networks over a broad range of tissues. It is evident that rather than being randomly organized events, pathophysiologies that possess a strong aging component such as cardiovascular diseases (hypertensions, atherosclerosis, and vascular stiffening) and neurodegenerative conditions (dementia, Alzheimer's disease, mild cognitive impairment, Parkinson's disease), in essence represent a subtly modified version of the intricate molecular programs already in place for normal aging. To control such multidimensional activities there are layers of trophic protein control across these networks mediated by so-called "keystone" proteins. We propose that these "keystones" coord

SUBMITTER: Hendrickx JO 

PROVIDER: S-EPMC6304357 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature